Where Motherhood Can Be Possible

Dr. Louis R. Manara

A Look At IVF Results With Poor Prognosis Patients


It is fair to say that the majority of infertile couples with access to care will be successful given the right combination of patience, determination, and good treatment.  However, there is a sub-group of patients who may not achieve success.  This sub-group of patients is often referred to as “poor responders”, this term being broadly applied to patients who do not respond vigorously to ovarian stimulation.  It is important to define this group clearly so that information obtained from multiple centers may be compared and looked at cumulatively.  In this blog post, we review a recent study that looked at results of  768 treatment cycles in a group of patients who were categorized as poor responders/poor prognosis patients.

More Evidence That Genetic Abnormalities Explain Age Related Infertility!

Mounting evidence suggests that the significant reduction in infertility treatment success as women age is mostly related to increased production of genetically abnormal (aneuploid) embryos with advancing years.  A recent multicenter study in which embryos were studied with PGD (preimplantation genetic diagnosis), demonstrated that the percentage of genetically abnormal embryos produced by women less than 35 years of age was 31.7%, while the percentage of genetically abnormal embryos produced by women 41-42 years of age was 76.3%.  However, when genetically normal embryos were available, the implantation rate was not significantly different across all age groups.

Voorhees, New Jersey

Dr. Louis R. Manara


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