Are male chromosomal abnormalities associated with repeated implantation failure and pregnancy loss?
Diagnosing male causes of recurrent pregnancy loss and repeated IVF failure can be quite difficult. It is well understood that the standard semen analysis will fail to identify all males with abnormally functioning sperm. Sperm count, motility, and microscopic assessment may all be quite normal in some men who have poor sperm quality and function. When a specific technique called fluorescence in-situ hybridization (FISH) is used to evaluate the sperm of men whose partners have experienced repeated pregnancy losses or multiple failed IVF treatments, an increased incidence of sperm chromosomal abnormalities has been found. If the sperm count, motility, and microscopic evaluation are abnormal in these patients, then the incidence of chromosomal abnormalities is even higher.