It is fair to say that the majority of infertile couples with access to care will be successful given the right combination of patience, determination, and good treatment. However, there is a sub-group of patients who may not achieve success. This sub-group of patients is often referred to as “poor responders”, this term being broadly applied to patients who do not respond vigorously to ovarian stimulation. It is important to define this group clearly so that information obtained from multiple centers may be compared and looked at cumulatively. In this blog post, we review a recent study that looked at results of 768 treatment cycles in a group of patients who were categorized as poor responders/poor prognosis patients.