Where Motherhood Can Be Possible

Dr. Louis R. Manara

Repeated IVF Failure: What Do We Know In 2013



Repeated in-vitro-fertilization (IVF) failure is perplexing for patients as well the infertility team providing care.  In spite of repeated placement of what appear to be healthy embryos, ongoing pregnancy does not occur.  These patients usually have had extensive evaluations that include careful evaluation of the uterine cavity, genetic testing of both parents, testing for clotting disorders (thrombophilias) in the woman, comprehensive endocrine assessment, and evaluation of the male.  Conventional wisdom has been that there is most likely a genetic explanation for these repeated failures.  That notion may be incorrect based on a recent study. 

Elective Single Embryo Transfer


Because of the known significant risks of multi-fetal gestation, there have been substantial efforts directed toward decreasing the number of multi-fetal pregnancies associated with assisted reproductive technologies (ART).  While efforts over the past 10 years have substantially reduced the number of triplet and higher order pregnancies, the incidence of twins remains unacceptably high among ART pregnancies.  Incentivizing elective single embryo transfer (eSET) is one of the methods being considered toward reducing the incidence of twins.  A recent abstract presented at the IFFS/ASRM conjoint meeting in Boston, October 16, 2013 reviewed  incentivizing eSET.  

Voorhees, New Jersey

Dr. Louis R. Manara


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